Dietary Pattern Study

Research question:

The aim of this human intervention study is to investigate the effects of three dietary patterns (Nordic, Vegetarian, and Western (Habitual)) on metabolism, immune system, and neurodegeneration in persons exhibiting metabolic syndrome characteristics. In addition, the composition and function of the gut microbiome are studied and epigenetic parameters related to neuroprotection are analyzed. In a follow-up, a cross-over with a subgroup of the study participants is performed and the role of the gut microbiota in the effects of the diets is analyzed in more detail.

Study Design and Procedure:

This is a prospective, monocentric, randomized, controlled clinical nutrition intervention study in a parallel-group design with cross-over design in follow-up.

During a 6-week nutritional intervention, the effects of the three dietary patterns are investigated in 120 individuals with metabolic syndrome characteristics. Study participants are randomized to one of three intervention groups:

  1. Nordic Diet
  2. Ovo-lacto-vegetarian diet
  3. Habitual diet


To implement the study diets (i and ii), isocaloric diet plans, which alternate at 14-day intervals, are provided for 3 main meals and 2 snacks, including beverages. The control group maintains their habitual diet.


In the follow-up study, a subgroup of the study participants are invited to participate in the study again. The participants are randomly assigned to one of the other two intervention groups in a cross-over and have repeated the 6-week intervention.

© none

Hanna Huber, M. Sc.

© none

Alina Schieren, M. Sc.

Katzenburgweg 7, 53115 Bonn  

+ 49 (0) 228 73-2018

© none

Jun.-Prof. Dr. Marie Christine Simon

Katzenburgweg 7, 53115 Bonn  

+ 49 (0) 228 73-3814

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